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Beyond individual trials, a 2025 meta-analysis covering over 140,000 participants found tirzepatide yields a mean 4.23% greater weight loss than semaglutide (95% CI: 3.22 5.25

Injectable semaglutide at equivalent therapeutic doses (2.4mg weekly Wegovy) produces average weight loss of 14.9% over 68 weeks in clinical trials

Semaglutide was a major focus of Trilliant Health's 2023 "Trends Shaping the Health Economy." The report reveals that sales of semaglutide (including Ozempic and Wegovy) totaled $10.7B in 2021

No Generic Available: Eli Lilly holds patents on tirzepatide until around 2036-2040, meaning no true generic versions will be available for years

(2021, September)

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